high-throughput on a single roller compactor. We also assess the accuracy of the developed model to transfer to a different roller compactor with a larger roll diameter. This is the first time a process modelling approach to scale-up from low to high-throughput has been presented in the literature for such a high drug loading of API.
The purpose of this study is to investigate if Johanson''s rolling theory can correctly predict the maximum roll surface pressure during the roll compaction. Three model pharmaceutical formulations were roller compacted using the Gerteis Mini Pactor at multiple coinations of roll forces and roll gaps. The resultant ribbon density at each
2016-12-8 · The study will focus on the dynamic model of a roller compactor as described in Shuo-Huan Hsu & Gintaras V. Reklaitis 2010 using Johanson‟ approach. Johanson was the first to come out with a mathematical model for granulated materials. The roll press has been used widely in the still industry.
high-throughput on a single roller compactor. We also assess the accuracy of the developed model to transfer to a different roller compactor with a larger roll diameter. This is the first time a process modelling approach to scale-up from low to high-throughput has been presented in the literature for such a high drug loading of API.
19 April 2011. GERTEIS to Exhibit its Roller Compactors and Dry Granulation Systems at INTERPHEX 2010. GERTEIS, a premium supplier of superior roller compactors and dry granulation systems, will be exhibiting its products at
Whether it’s a soil compactor, or a mini tandem roller, all JCB compactors are remarkably cost-effective and offer excellent productivity. We now bring to you the new JCB VM117 Compactor that comes with a CEV Stage IV compliant engine, ensuring enhanced performance. The machine is equipped with LiveLink, an advanced telematics technology, and
Compaction Equipment. JCB’s range of vibratory compaction machinery covers every base. Whether you’re looking for a trench roller, a double drum, a tandem roller or a single drum soil compactor. With Compaction''s heritage in the soil compaction market, and our reputation for build quality and design innovation, our range delivers unrivalled
2020-5-1 · An approximate analytical solution to Johanson’s rolling theory is derived.¹ It is shown that the solution yields a single dimensionless parameter
GYROCOMP gyratory compactor, internal angle of gyration pre-set to 0.82°to EN 12697-31 Annex B. 230-110V/50-60Hz/1ph. Units. icon check. icon bag. Quote added. Technical Specifiions. Compacted specimen size: 150 and 100 mm dia. Sample height: 80 to 200 mm (150 mm)-50 to 125 mm (100 mm)
2012-6-18 · The placebo model was then used to calculate scale up parameters from WP120 to WP200 roller compactor. While WP120 has a single screw speed, WP200 is equipped with a twin feed screw system. A limited nuer of roller compaction runs on WP200 was used as a calibration set to determine normal stress profile across ribbon width.
2022-3-21 · The first equation from the Johanson model describes the pressure gradient for the direction parallel to the rollers, assuming that slip occurs along the roll surface. The ribbons were produced using a lab-scale roller compactor (Alexanderwerks, Remsheid, Germany) with diamond knurl and flat rollers of a 12 cm diameter and 4 cm width. For
2010-3-18 · In this study, we focus on the dynamic model of a roller compactor with one fixed and one movable roll. Three key process parameters of the roller compactor are speeds of the auger and the roll (in rpm) and the roll pressure (in MPa), and the output variables of interest are the ribbon density (in g/cm 3) and the gap width (in mm).Given the ribbon density, other properties
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2021-5-15 · The purpose of the study is to build a “virtual roller compactor” as a predictive tool to assess the roll force (RF)-maximum pressure (P max) and RF-ribbon density relationship for pharmaceutical roller compaction.We provided a theoretical basis to demonstrate that, there exists a critical nip angle for a pharmaceutical powder, beyond which the RF-P max
2012-10-15 · The roll force approach from Johanson model was successfully applied in scale up from pilot scale WP120 to commercial scale WP200 roller compactor. The proposed scale up approach is not limited to any specific roller compactor; it can be applied to any commercial roller compactor provided the relationship between RFU vs. hydraulic roll pressure
2020-4-15 · The Johanson model applies to the nip and slip regions in the roller compactor (see Fig. 1). Any elastic recovery in the release region is not modelled. The coordinate system adopted is as shown in Fig. 1, with the x-axis in the direction
The purpose of the study is to build a "virtual roller compactor" as a predictive tool to assess the roll force (RF)-maximum pressure (P max) and RF-ribbon density relationship for pharmaceutical roller compaction.We provided a theoretical basis to demonstrate that, there exists a critical nip angle for a pharmaceutical powder, beyond which the RF-P max relationship is insensitive to
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Johanson’s roll compaction model [J.R. Johanson, A rolling theory for granular solids, ASME Journal of Applied Mechanics E32 (1965) 842–848] is modified to improve its predictions of a compacted ribbon’s relative density. Previous work has shown that the maximum roll pressure and ribbon relative density predicted by the Johanson model are not only larger than those
Roller compaction (RC) is a dry granulation technique applied to improve the flow and compressibility of drug formulations. RC implementation for high drug load formulations can be challenging due to flow issues and a high consumption of active pharmaceutical ingredient (API) for robust process development.
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Abstract. The impact of material properties and process parameters are determined using a continuum model. Normal stresses for roller compaction are calculated from Johanson''s rolling theory. The boundary between the slip and nip regions is calculated using Johanson''s criterion, i.e. gradients of stress in slip and nip regions are assumed to be
In roller compaction, the nip angle defines the critical transition interface between the slip and nip regions which is used to model material densifiion behavior and the properties of compacted ribbons. Experimental input relating to roll geometry, powder density, and mass output from the compactor were required and they could be
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2012-10-15 · DOI: 10.1016/j.ijpharm.2012.06.027 Corpus ID: 1968912; Roller compaction process development and scale up using Johanson model calibrated with instrumented roll data. @article{Nesarikar2012RollerCP, title={Roller compaction process development and scale up using Johanson model calibrated with instrumented roll data.}, author={Vishwas V. Nesarikar